Phosgene → HCID 13424424, compound

HRID 462605Notes

Reaction equation

HRID 462605 reaction equation
[C:1](=O)([O-])[O-:2].[K+].[K+].[CH3:7][O:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[NH:15][C:16]1[CH:24]=[CH:23][CH:22]=[CH:21][C:17]=1[C:18]([OH:20])=[O:19].C(Cl)(Cl)=O>C1(C)C=CC=CC=1.O>[CH3:7][O:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[N:15]1[C:1](=[O:2])[O:20][C:18](=[O:19])[C:17]2=[CH:21][CH:22]=[CH:23][CH:24]=[C:16]12

Participants

6

Reactant 3

HCID 6371PhosgeneHCID 11430Potassium CarbonateHCID 202774Anthranilic acid, N-(2-methoxyphenyl)-

Product 1

HCID 13424424HCID 13424424, compoundYield 22.1%

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 1140TolueneSolvent

Procedure

To a suspension of 24.44 g (0.177 mole) of potassium carbonate in 119 ml of toluene and 238 ml of water, stirred at 20°-40° C., was added 28.61 g (0.1176 mole) of 2-(2-methoxyphenylamino)benzoic acid, and phosgene was bubbled through the mixture for a period of 3.5 hours. The reaction was allowed to stand overnight with stirring, and the solid material was collected by filtration. The latter was dissolved in ethyl acetate and added to the toluene layer separated from the filtrate. The solution was washed twice with 200 ml 1N potassium hydroxide and dried over anhydrous magnesium sulfate. The solvent was removed in vacuo to yield 7 g of N-(2-methoxyphenyl)isatoic anhydride.

Workup

  1. customwas bubbled through the mixture for a period of 3.5 hours
  2. stirringwith stirring
  3. filtrationthe solid material was collected by filtration
  4. dissolutionThe latter was dissolved in ethyl acetate
  5. additionadded to the toluene layer
  6. customseparated from the filtrate
  7. washThe solution was washed twice with 200 ml 1N potassium hydroxide
  8. dry with materialdried over anhydrous magnesium sulfate
  9. customThe solvent was removed in vacuo

Sources & evidence

ORD record
ord-e77ce28f2a7549a6b25f9b0482d7a017
Source dataset
uspto-grants-1985_05
Patent number
US04515980

Reaction notes

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