Hydrogen Cyanide → 2-(2-Fluoro-4-trifluoromethylphenylamino)-3-methylbutyronitrile

HRID 462661Notes

Reaction equation

HRID 462661 reaction equation
ClC1C=[C:4](C(F)(F)F)[CH:5]=[CH:6][C:7]=1[NH2:8].[F:13][C:14]1[CH:15]=[C:16]([C:21]([F:24])([F:23])[F:22])[CH:17]=[CH:18][C:19]=1[NH2:20].C#N.[CH:27](=O)C(C)C>O>[F:13][C:14]1[CH:15]=[C:16]([C:21]([F:22])([F:23])[F:24])[CH:17]=[CH:18][C:19]=1[NH:20][CH:6]([CH:5]([CH3:27])[CH3:4])[C:7]#[N:8]

Participants

6

Reactant 4

HCID 768Hydrogen CyanideHCID 6561IsobutyraldehydeHCID 1620012-Chloro-4-trifluoromethylanilineHCID 27376742-Fluoro-4-(trifluoromethyl)aniline

Product 1

HCID 202839842-(2-Fluoro-4-trifluoromethylphenylamino)-3-methylbutyronitrile

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Following the procedure of Example 1, each of 3-chloro-4-aminobenzotrifluoride and 3-fluoro-4-aminobenzotrifluoride is reacted with hydrogen cyanide and isobutyraldehyde, in a neat, initially water-free system, to give the respective nitrile, 2-(2-chloro-4-trifluoro-methylphenylamino)-3-methylbutyronitrile and 2-(2-fluoro-4-trifluoromethylphenylamino)-3-methylbutyronitrile.

Sources & evidence

ORD record
ord-f4fb8e7036e843d7865338e8ca199b44
Source dataset
uspto-grants-1985_05
Patent number
US04517130

Reaction notes

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