Dimethylamine → HCID 13488555, compound

HRID 462665Notes

Reaction equation

HRID 462665 reaction equation
[NH2:1][C:2]1[C:7]([C:8]#[N:9])=[N:6][C:5]([C:10]#[N:11])=[C:4](Cl)[N:3]=1.[CH3:13][NH:14][CH3:15]>O1CCCC1>[NH2:1][C:2]1[C:7]([C:8]#[N:9])=[N:6][C:5]([C:10]#[N:11])=[C:4]([N:14]([CH3:15])[CH3:13])[N:3]=1

Participants

4

Reactant 2

HCID 674DimethylamineHCID 27867412,6-Pyrazinedicarbonitrile, 3-amino-5-chloro-

Product 1

HCID 13488555HCID 13488555, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

The starting material, 2-amino-6-chloro-3,5-dicyanopyrazine (100 mg; 0.557 mM), is prepared in accordance with the method described by Perchais and Fleury in Tetrahedron, 30:999-1009 (1974), and stirring in 1 ml of dry tetrahydrofuran. There was then added dropwise 0 54 ml of a chilled solution of dimethylamine gas in tetrahydrofuran (93 mg/ml) over 10 minutes. The reaction mixture was then stirred at room temperature for 0.5 hours; the product was removed by centrifuging, and then recrystallized from 1:1 ethanol/i-propanol (50 mg); m.p. 201°-202° C.

Workup

  1. customthe product was removed by centrifuging
  2. customrecrystallized from 1:1 ethanol/i-propanol (50 mg)

Sources & evidence

ORD record
ord-7e84c11c82c8456a972f3d67373fb516
Source dataset
uspto-grants-1985_05
Patent number
US04517186

Reaction notes

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