Ammonia → HCID 13365242, compound

HRID 462668Notes

Reaction equation

HRID 462668 reaction equation
[CH:1]([C:3]1[CH:13]=[C:12]([CH3:14])[C:6]([C:7]([O:9][CH2:10][CH3:11])=[O:8])=[C:5]([CH3:15])[C:4]=1[NH:16][C:17](=O)[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)=O.[NH3:25]>>[C:18]1([C:17]2[N:25]=[CH:1][C:3]3[C:4](=[C:5]([CH3:15])[C:6]([C:7]([O:9][CH2:10][CH3:11])=[O:8])=[C:12]([CH3:14])[CH:13]=3)[N:16]=2)[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1

Participants

3

Reactant 2

HCID 222AmmoniaHCID 20397057Ethyl 3-benzamido-4-formyl-2,6-dimethylbenzoate

Product 1

HCID 13365242HCID 13365242, compound

Procedure

Ethyl 4-formyl-2,6-dimethyl-3-benzoylaminobenzoate was used instead of the compound of formula (II) used in Example 1 and reacted with ammonia in the same way as in Example 1. The reaction product was chromatographed on a silica gel column in the same way as in Example 1. The solvent was evaporated, and the residue was recrystallized from diethyl ether/n-hexane to give 2-phenyl-7-ethoxycarbonyl-6,8-dimethylquinazoline having a melting point of 85° to 86° C. in a yield of 35% by weight.

Workup

  1. customThe reaction product was chromatographed on a silica gel column in the same way as in Example 1
  2. customThe solvent was evaporated
  3. customthe residue was recrystallized from diethyl ether/n-hexane

Sources & evidence

ORD record
ord-3f8dbe22567c4149acabc81863eb6b7f
Source dataset
uspto-grants-1985_05
Patent number
US04517189

Reaction notes

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