Ammonia → HCID 13365246, compound

HRID 462671Notes

Reaction equation

HRID 462671 reaction equation
[CH:1]([C:3]1[CH:13]=[C:12]([CH3:14])[C:6]([C:7]([O:9][CH2:10][CH3:11])=[O:8])=[C:5]([CH3:15])[C:4]=1[NH:16][C:17](=O)[CH3:18])=O.[NH3:20]>>[CH3:18][C:17]1[N:20]=[CH:1][C:3]2[C:4](=[C:5]([CH3:15])[C:6]([C:7]([O:9][CH2:10][CH3:11])=[O:8])=[C:12]([CH3:14])[CH:13]=2)[N:16]=1

Participants

3

Reactant 2

HCID 222AmmoniaHCID 20397050HCID 20397050, compound

Product 1

HCID 13365246HCID 13365246, compoundYield 40%

Procedure

Instead of the compound of formula (II) used in Example 1, ethyl 4-formyl-2,6-dimethyl-3-acetylaminobenzoate was used and reacted with ammonia in the same way as in Example 1. The reaction product was chromatographed on a silica gel column in the same way as in Example 1. The solvent was evaporated, and the residue was recrystallized from ethanol/water to give 2-methyl-7-ethoxycarbonyl-6,8-dimethylquinazoline having a melting point of 84° to 86° C. in a yield of 40%.

Workup

  1. customThe reaction product was chromatographed on a silica gel column in the same way as in Example 1
  2. customThe solvent was evaporated
  3. customthe residue was recrystallized from ethanol/water

Sources & evidence

ORD record
ord-e04ed26d8ffb47aaa6b51679729412ed
Source dataset
uspto-grants-1985_05
Patent number
US04517189

Reaction notes

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