Sodium Bicarbonate → HCID 20397105, compound

HRID 462702Notes

Reaction equation

HRID 462702 reaction equation
[S:1]1[C:5]2=[CH:6][C:7]3[CH:8]=[CH:9][CH:10]=[CH:11][C:12]=3[C:4]2=[N:3][CH:2]1[NH:13][C:14](=[O:20])[C:15]([O:17]CC)=[O:16].C([O-])(O)=O.[Na+]>O>[S:1]1[C:5]2=[CH:6][C:7]3[CH:8]=[CH:9][CH:10]=[CH:11][C:12]=3[C:4]2=[N:3][CH:2]1[NH:13][C:14](=[O:20])[C:15]([OH:17])=[O:16]

Participants

4

Reactant 2

HCID 516892Sodium BicarbonateHCID 20397104HCID 20397104, compound

Product 1

HCID 20397105HCID 20397105, compoundYield 93%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

3.5 g (0.012 mole) of ethyl N-(indeno[1,2-d]thiazol-2-yl)-oxamate were suspended in a solution of 1.1 g (0.013 mole) of NaHCO3 in 200 ml of water, and the suspension was refluxed for 4 hours. The reaction mixture was filtered, the filtrate was brought to pH 1 with dilute HCl, and the precipitate was filtered off under suction and dried, giving 2.9 g (93%) of a product of melting point 229°-231° C.

Workup

  1. temperaturethe suspension was refluxed for 4 hours
  2. filtrationThe reaction mixture was filtered
  3. filtrationthe precipitate was filtered off under suction
  4. customdried

Sources & evidence

ORD record
ord-48adfcff239444bf801938fb2a212b3d
Source dataset
uspto-grants-1985_05
Patent number
US04517196

Reaction notes

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