Pyridine → HCID 70400290, compound

HRID 462886Notes

Reaction equation

HRID 462886 reaction equation
ClC1C=CC(C2([CH2:16][Br:17])CCC(CCC)O2)=CC=1.[CH2:18]([CH:20]([C:24]([C:26]1C=CC(Cl)=CC=1)=C)[CH2:21][CH2:22][OH:23])C.BrBr.N1[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=1.Cl[CH2:42][Cl:43]>>[Cl:43][C:42]1[CH:40]=[CH:39][C:38]([C:16]2([Br:17])[C:20]([CH3:18])([CH2:24][CH3:26])[CH2:21][CH2:22][O:23]2)=[CH:37][CH:36]=1

Participants

6

Reactant 5

HCID 1049PyridineHCID 6344DichloromethaneHCID 24408BromineHCID 13235820HCID 13235820, compoundHCID 20281483HCID 20281483, compound

Product 1

HCID 70400290HCID 70400290, compound

Procedure

By the cyclisation procedure described for the preparation of 2-(4-chlorophenyl)-2-bromomethyl-5-prop-1-yltetrahydrofuran (see Example 1), 3-ethyl-4-(4-chlorophenyl)pent-4-en-1-ol (1.20 g), bromine (0.86 g), and pyridine (0.43 g) in dichloromethane gave 2-(4-chlorophenyl)-2-bromo-methyl-3-ethyltetrahydrofuran (1.60 g) as a red oil.

Sources & evidence

ORD record
ord-8305737ea4e24c048483d16239f72c1d
Source dataset
uspto-grants-1985_05
Patent number
US04518415

Reaction notes

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