Hydrochloric Acid → HCID 20281492, compound

Participants

Reaction Steps

3-(4-Chlorobenzoyl)-2,2-dimethylpropionic acid (13.7 g) was dissolved in ethanol (100 ml) which had been saturated with gaseous hydrogen chloride. The solution as refluxed for eight hours. The solvent was distilled off and replaced by ether. The ethereal solution was washed with saturated sodium bicarbonate solution, then with brine, dried over magnesium sulphate and concentrated in vacuo to yield 14.5 g of ethyl 3-(4-chlorobenzoyl)-2,2-dimethylpropionate as an oil.

Provenance & Evidence