Hydrochloric Acid → HCID 20281492, compound

HRID 462892Notes

Reaction equation

HRID 462892 reaction equation
[Cl:1][C:2]1[CH:16]=[CH:15][C:5]([C:6]([CH2:8][C:9]([CH3:14])([CH3:13])[C:10]([OH:12])=[O:11])=[O:7])=[CH:4][CH:3]=1.Cl.[CH2:18](O)[CH3:19]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:6]([CH2:8][C:9]([CH3:13])([CH3:14])[C:10]([O:12][CH2:18][CH3:19])=[O:11])=[O:7])=[CH:15][CH:16]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 2028147958457-63-9

Product 1

HCID 20281492HCID 20281492, compound

Procedure

3-(4-Chlorobenzoyl)-2,2-dimethylpropionic acid (13.7 g) was dissolved in ethanol (100 ml) which had been saturated with gaseous hydrogen chloride. The solution as refluxed for eight hours. The solvent was distilled off and replaced by ether. The ethereal solution was washed with saturated sodium bicarbonate solution, then with brine, dried over magnesium sulphate and concentrated in vacuo to yield 14.5 g of ethyl 3-(4-chlorobenzoyl)-2,2-dimethylpropionate as an oil.

Workup

  1. temperatureThe solution as refluxed for eight hours
  2. distillationThe solvent was distilled off
  3. washThe ethereal solution was washed with saturated sodium bicarbonate solution
  4. dry with materialwith brine, dried over magnesium sulphate
  5. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-a5e4cf63818d4894a037de3778f4cf3b
Source dataset
uspto-grants-1985_05
Patent number
US04518415

Reaction notes

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