HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chlorobenzaldehyde → Ethyl 4-(4-chlorophenyl)-4-oxobutanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chlorobenzaldehyde | HCID 7726 | — |
| Reactant | Ethyl Acrylate | HCID 8821 | — |
| Reactant | Sodium Cyanide | HCID 8929 | — |
| Reactant | (4-Chlorophenyl)-gamma-(1,2,4-triazol-1-yl)methyl-gamma-butyrolactone | HCID 20281490 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Ethyl 4-(4-chlorophenyl)-4-oxobutanoate | HCID 10490261 | 83% |
Reaction Steps
This Example illustrates the preparation of -(4-chlorophenyl)-γ-(1,2,4-triazol-1-yl)methyl-γ-butyrolactone (A). ##STR45## Ethyl 3-(4-chlorobenzoyl)propanoate (25.0 g, 83%) was prepared from 4-chlorobenzaldehyde (23.4 g), ethyl acrylate (12.5 g) and sodium cyanide (4.0 g) in dimethylformamide (DMF: 300 ml) by the method described for the preparation of the corresponding methyl ester in Example 1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04518415 |
| Source dataset | uspto-grants-1985_05 |
| ORD ID | ord-faa347f976764f0e9ca19e596eafa5ac |
| Source note | uspto-grants-1985_05 |