Acetic Acid → HCID 9922602, compound

HRID 462934Notes

Reaction equation

HRID 462934 reaction equation
[OH:1][C:2]1[CH:30]=[C:29]2[C:5]([NH:6][CH:7]=[C:8]2[CH2:9][C@@H:10]([C:12]([NH:14][C@H:15]([C:26]([OH:28])=[O:27])[CH2:16]C2C3C(=CC=CC=3)NC=2)=[O:13])[NH2:11])=[CH:4][CH:3]=1.C(O)(=[O:33])C>Cl>[OH:1][C:2]1[CH:30]=[C:29]2[C:5]([NH:6][CH:7]=[C:8]2[CH2:9][C@@H:10]([C:12]([NH:14][C@H:15]([C:26]([OH:28])=[O:27])[CH2:16][OH:33])=[O:13])[NH2:11])=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 176Acetic AcidHCID 10294745HCID 10294745, compound

Product 1

HCID 9922602HCID 9922602, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

3.4 g (6.8 mmol) of the derivative obtained above according to (b) are dissolved in 25 ml of acetic acid saturated with hydrochloric acid, the solution is stirred for a few hours at ordinary temperature, the product is then precipitated in excess ethyl ether and filtered off and the precipitate is dried to give the title derivative in the pure state, which is identical to the product obtained according to Example 16.

Workup

  1. custom3.4 g (6.8 mmol) of the derivative obtained
  2. customthe product is then precipitated in excess ethyl ether
  3. filtrationfiltered off
  4. customthe precipitate is dried
  5. customto give the title derivative in the pure state, which
  6. customobtained

Sources & evidence

ORD record
ord-7dbe6c7b862746cb9c218a6bca3bba6b
Source dataset
uspto-grants-1985_05
Patent number
US04518587

Reaction notes

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