Water → HCID 13531509, compound

HRID 462938Notes

Reaction equation

HRID 462938 reaction equation
[NH2:1][C:2]1[C:7]([C:8]#[N:9])=[N:6][C:5]([Cl:10])=[C:4]([NH:11][CH2:12][CH2:13][OH:14])[N:3]=1.[C:15](OC(=O)C)(=[O:17])[CH3:16].O>N1C=CC=CC=1>[NH2:1][C:2]1[C:7]([C:8]#[N:9])=[N:6][C:5]([Cl:10])=[C:4]([NH:11][CH2:12][CH2:13][O:14][C:15](=[O:17])[CH3:16])[N:3]=1

Participants

5

Reactant 3

HCID 962WaterHCID 7918Acetic AnhydrideHCID 13531507HCID 13531507, compound

Product 1

HCID 13531509HCID 13531509, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

The product of Example 2, 2-amino-5 chloro-3-cyano-6-[(2-hydroxyethyl)amino]pyrazine (68 mg), was dissolved in pyridine (0.5 ml) and there was then added acetic anhydride (0.5 ml). The reaction mixture was stirred at room temperature for 2 hours, at which point thin layer chromatography showed no starting material remaining. Ice and then water were added to the reaction mixture, after which it was stirred for an additional 15 minutes. The product precipitated, was filtered, washed once with water, and dried (62.7 mg). Elemental Analysis for C9H10N5O2Cl:

Workup

  1. stirringafter which it was stirred for an additional 15 minutes
  2. customThe product precipitated
  3. filtrationwas filtered
  4. washwashed once with water
  5. customdried (62.7 mg)

Sources & evidence

ORD record
ord-a82938b555de483db3d4d92b643e3637
Source dataset
uspto-grants-1985_05
Patent number
US04518599

Reaction notes

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