Acetic Anhydride → HCID 13531510, compound

HRID 462940Notes

Reaction equation

HRID 462940 reaction equation
[NH2:1][C:2]1[C:7]([C:8]#[N:9])=[N:6][C:5]([Cl:10])=[C:4]([S:11][CH2:12][CH2:13][NH2:14])[N:3]=1.[C:15](OC(=O)C)(=[O:17])[CH3:16]>N1C=CC=CC=1>[NH2:1][C:2]1[C:7]([C:8]#[N:9])=[N:6][C:5]([Cl:10])=[C:4]([S:11][CH2:12][CH2:13][NH:14][C:15](=[O:17])[CH3:16])[N:3]=1

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 13531515HCID 13531515, compound

Product 1

HCID 13531510HCID 13531510, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

The product of Example 9 above, 2-amino-5-chloro-3-cyano-6-[(2-aminoethyl)thio]pyrazine (50 mg), was suspended in pyridine (0.5 ml), to which acetic anhydride (0.5 ml) was then added. The reaction mixture was stirred at room temperature overnight (18 hours), after which ice was added. The product precipitated, was filtered, and washed with water (10 mg).

Workup

  1. additionwas then added
  2. additionafter which ice was added
  3. customThe product precipitated
  4. filtrationwas filtered
  5. washwashed with water (10 mg)

Sources & evidence

ORD record
ord-9e869501d1184417a87bca3eaa70e2fa
Source dataset
uspto-grants-1985_05
Patent number
US04518599

Reaction notes

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