Hydrochloric Acid → HCID 20150140, compound

HRID 462943Notes

Reaction equation

HRID 462943 reaction equation
C([N:3]1[CH2:8][CH2:7][N:6]([C:9]2[N:10]=[C:11]([N:21]3[CH2:26][CH2:25][O:24][CH2:23][CH2:22]3)[C:12]3[N:18]=[CH:17][N:16]=[C:15]([S:19][CH3:20])[C:13]=3[N:14]=2)[CH2:5][CH2:4]1)=O.Cl>C(O)C>[CH3:20][S:19][C:15]1[C:13]2[N:14]=[C:9]([N:6]3[CH2:5][CH2:4][NH:3][CH2:8][CH2:7]3)[N:10]=[C:11]([N:21]3[CH2:22][CH2:23][O:24][CH2:25][CH2:26]3)[C:12]=2[N:18]=[CH:17][N:16]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 20150154HCID 20150154, compound

Product 1

HCID 20150140HCID 20150140, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

1.5 gm (0.004 mol) of 2-(N-formyl-piperazino)-8-methylthio-4-morpholino-pyrimido-[5,4-d]-pyrimidine (m.p.: 205°-207° C.) were dissolved in 200 ml of absolute ethanol. After addition of 10 ml of ethanolic hydrochloric acid, the solution was refluxed for 20 minutes. The solvent was then evaporated in vacuo, and the residue was taken up in about 50 ml of water. The resulting solution of the hydrochloride was adjusted to about pH 10, whereby the free base was obtained as an initially oily precipitate which soon solidified. The precipitate was suction-filtered off, washed well with water and dried.

Workup

  1. temperaturethe solution was refluxed for 20 minutes
  2. customThe solvent was then evaporated in vacuo
  3. customwas obtained as an initially oily precipitate which
  4. filtrationThe precipitate was suction-filtered off
  5. washwashed well with water
  6. customdried

Sources & evidence

ORD record
ord-b94bfbacd52b46c39de7edd2c0345b06
Source dataset
uspto-grants-1985_05
Patent number
US04518596

Reaction notes

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