Piperazine → 8-Ethoxy-4-morpholino-2-piperazino-pyrimido-[5,4-d]-pyrimidine

HRID 462963Notes

Reaction equation

HRID 462963 reaction equation
[CH2:1]([O:3][C:4]1[C:9]2[N:10]=[C:11](Cl)[N:12]=[C:13]([N:14]3[CH2:19][CH2:18][O:17][CH2:16][CH2:15]3)[C:8]=2[N:7]=[CH:6][N:5]=1)[CH3:2].[NH:21]1[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1>>[CH2:1]([O:3][C:4]1[C:9]2[N:10]=[C:11]([N:21]3[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]3)[N:12]=[C:13]([N:14]3[CH2:19][CH2:18][O:17][CH2:16][CH2:15]3)[C:8]=2[N:7]=[CH:6][N:5]=1)[CH3:2]

Participants

3

Reactant 2

HCID 4837PiperazineHCID 201501578-Ethoxy-2-chloro-4-morpholino-pyrimido-[5,4-d]-pyrimidine

Product 1

HCID 201502938-Ethoxy-4-morpholino-2-piperazino-pyrimido-[5,4-d]-pyrimidine

Procedure

This compound was prepared analogous to Example 2 from 8-ethoxy-2-chloro-4-morpholino-pyrimido-[5,4-d]-pyrimidine (m.p.: 153°-155° C.) and piperazine.

Sources & evidence

ORD record
ord-a42dfead01b44747831d3d7b76a08a8d
Source dataset
uspto-grants-1985_05
Patent number
US04518596

Reaction notes

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