反应详情

To a suspension of (5-fluoro-2-hydroxyphenyl)boronic acid (1.000 g, 0.00641 mol) in toluene (3.0 ml) was added pinacol (0.875 g, 0.007404 mol). This was heated to reflux using a Dean-Stark apparatus for 24 hours before concentrating in vacuo. The residue was suspended in tert-butyl-methyl ether (10.0 ml) and organic layer was washed with saturated aqueous sodium chloride solution (2×10.0 ml), dried over sodium sulphate, filtered and concentrated in vacuo to afford the title compound as a translucent oil, 1.4 g, 92% yield.

1. temperatureThis was heated
2. temperatureto reflux
3. customfor 24 hours
4. concentrationbefore concentrating in vacuo
5. washorganic layer was washed with saturated aqueous sodium chloride solution (2×10.0 ml)
6. dry with materialdried over sodium sulphate
7. filtrationfiltered
8. concentrationconcentrated in vacuo