反应详情

A solution of 6-bromo-2-methylhexanoic acid (1.08 g, 5.17 mmole) and triphenylphosphine (1.42 g, 5.4 mmole) in toluene (5 ml) was heated under reflux for 18 hours. After the solution was cooled, the crystals which separated out were collected by filtration and washed with toluene and ethyl acetate to yield 5-carboxy-5-methylpentyltriphenylphosphonium bromide (1.6 g, 64%).

1. temperatureunder reflux for 18 hours
2. temperatureAfter the solution was cooled
3. customthe crystals which separated out
4. filtrationwere collected by filtration
5. washwashed with toluene and ethyl acetate