HCID 13417296, compound → HCID 13417295, compound

HRID 463057Notes

Reaction equation

HRID 463057 reaction equation
[CH3:1][C:2]([CH3:22])([CH2:6][CH2:7][CH2:8]/[CH:9]=[C:10](/[C:16]1[CH:17]=[N:18][CH:19]=[CH:20][CH:21]=1)\[C:11]1[S:12][CH:13]=[CH:14][CH:15]=1)[C:3]([OH:5])=[O:4]>P(=O)(O)(O)O>[CH3:1][C:2]([CH3:22])([CH2:6][CH2:7][CH2:8]/[CH:9]=[C:10](\[C:16]1[CH:17]=[N:18][CH:19]=[CH:20][CH:21]=1)/[C:11]1[S:12][CH:13]=[CH:14][CH:15]=1)[C:3]([OH:5])=[O:4]

Participants

3

Reactant 1

HCID 13417296HCID 13417296, compound

Product 1

HCID 13417295HCID 13417295, compoundYield 48%

Reagents, catalysts & solvents 1

HCID 1004Phosphoric AcidSolvent

Procedure

(Z)-2,2-dimethyl-7-(3-pyridyl)-7-(2-thienyl)-6-heptenoic acid (1.0 g) was heated in 50% aqueous phosphoric acid (20 ml) at 100° C. for 20 hours, and the product was separated and extracted in the conventional manner. High performance liquid chromatography of this crude product revealed that its E isomer/Z isomer ratio was E/Z=56:23. The crude product was separated in the same manner as Example 2 to give (E)-2,2-dimethyl-7-(3-pyridyl)-7-(2-thienyl)-6-heptenoic acid (0.48 g).

Workup

  1. customthe product was separated
  2. extractionextracted in the conventional manner
  3. customThe crude product was separated in the same manner as Example 2

Sources & evidence

ORD record
ord-4ca5d3114f1a4a67b9b3d5912a235b63
Source dataset
uspto-grants-1985_05
Patent number
US04518602

Reaction notes

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