反应详情

One hundred thirty-three grams (0.63 mol) of methyl 3-methoxy-2-nitro-benzoate are dissolved in 1000 ml of toluene and hydrogenated in an autoclave at ambient temperature and under a hydrogen pressure of 5 bar in the presence of platinum over a period of two hours. The catalyst is removed by filtration, the residue is dried with sodium sulfate, and the toluene is distilled off in vacuo. Oil, RF value: 0.8 [silica gel plate; chloroform/acetone (9:1)],

1. customhydrogenated in an autoclave at ambient temperature and under a hydrogen
2. customof two hours
3. customThe catalyst is removed by filtration
4. dry with materialthe residue is dried with sodium sulfate
5. distillationthe toluene is distilled off in vacuo