Acetic Acid → HCID 20281862, compound

HRID 463069Notes

Reaction equation

HRID 463069 reaction equation
C([O:4][C:5]1[CH:6]=[C:7]([Cl:16])[C:8]2[NH:13][C:12](=[O:14])[O:11][CH2:10][C:9]=2[CH:15]=1)(=O)C.[OH-].[Na+].O.C(O)(=O)C>CO>[Cl:16][C:7]1[C:8]2[NH:13][C:12](=[O:14])[O:11][CH2:10][C:9]=2[CH:15]=[C:5]([OH:4])[CH:6]=1

Participants

6

Reactant 4

HCID 176Acetic AcidHCID 962WaterHCID 14798Sodium HydroxideHCID 20281687HCID 20281687, compound

Product 1

HCID 20281862HCID 20281862, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

An amount of 7.6 gm (31.4 mol) of 6-acetoxy-8-chloro-4H-3,1-benzoxazin-2-one is suspended in 50 ml of methanol, and 20 ml (40 mmol) of 2N sodium hydroxide solution are added, under stirring. The clear solution which is immediately produced is stirred for a further ten minutes at ambient temperature, water is added, and the mixture is made acidic with acetic acid. The precipitate is subjected to suction filtration and recrystallized from isopropanol.

Workup

  1. customThe clear solution which is immediately produced
  2. stirringis stirred for a further ten minutes at ambient temperature
  3. filtrationThe precipitate is subjected to suction filtration
  4. customrecrystallized from isopropanol

Sources & evidence

ORD record
ord-0f41d104fe9b414e8c9485fb33598bbe
Source dataset
uspto-grants-1985_05
Patent number
US04518597

Reaction notes

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