Acetic Acid → HCID 20281862, compound

Participants

Reaction Steps

An amount of 7.6 gm (31.4 mol) of 6-acetoxy-8-chloro-4H-3,1-benzoxazin-2-one is suspended in 50 ml of methanol, and 20 ml (40 mmol) of 2N sodium hydroxide solution are added, under stirring. The clear solution which is immediately produced is stirred for a further ten minutes at ambient temperature, water is added, and the mixture is made acidic with acetic acid. The precipitate is subjected to suction filtration and recrystallized from isopropanol.

Provenance & Evidence