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HRID46327

反应详情

EQUATION

反应方程式

HRID 46327 的结构方程式

REACTANTS

反应物

2
结构：O=S(=O)(Cl)c1cc(F)c(F)cc1F
HCID2776979

2,4,5-trifluorobenzenesulfonyl Chloride

C6H2ClF3O2S

结构：COc1ccc(CNc2ncc(Cl)s2)c(OC)c1
HCID57732151

未命名化合物

PRODUCTS

生成物

1
结构：COc1ccc(CN(c2ncc(Cl)s2)S(=O)(=O)c2cc(F)c(F)cc2F)c(OC)c1
HCID59436501

未命名化合物

PROCEDURE

实验过程

Prepared according to Preparation 333 using 5-chloro-N-(2,4-dimethoxybenzyl)-1,3-thiazol-2-amine (Preparation 208) and 2,4,5-trifluorobenzenesulfonyl chloride. Purification using ISCO™ (12 g SiO2) eluting with ethyl acetate:heptane (gradient 0:1 to 3:7, by volume) afforded the title compound as an orange solid.

WORKUP

后处理

  1. customPrepared
  2. customPurification
  3. washeluting with ethyl acetate