2,4,5-Trifluorobenzenesulfonyl chloride → N-(5-chloro-1,3-thiazol-2-yl)-N-(2,4-dimethoxybenzyl)-2,4,5-trifluorobenzenesulfonamide

Participants

Role	Name	HCID	Charge
Reactant	2,4,5-Trifluorobenzenesulfonyl chloride	HCID 2776979	—
Reactant	5-chloro-N-(2,4-dimethoxybenzyl)-1,3-thiazol-2-amine	HCID 57732151	—
Product	N-(5-chloro-1,3-thiazol-2-yl)-N-(2,4-dimethoxybenzyl)-2,4,5-trifluorobenzenesulfonamide	HCID 59436501	—

Reaction Steps

Prepared according to Preparation 333 using 5-chloro-N-(2,4-dimethoxybenzyl)-1,3-thiazol-2-amine (Preparation 208) and 2,4,5-trifluorobenzenesulfonyl chloride. Purification using ISCO™ (12 g SiO2) eluting with ethyl acetate:heptane (gradient 0:1 to 3:7, by volume) afforded the title compound as an orange solid.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08541588B2
Source dataset	uspto-grants-2013_09
ORD ID	ord-ffe806c09b414896b643a0622bdf64fb
Source note	uspto-grants-2013_09