反应详情

A mixture of 1-[4-(4-chlorophenyl)-2-hydroxy-n-butyl]imidazole (20 g) in dry pyridine (100 ml) was cooled in an ice bath and treated dropwise with stirring with 7.0 ml of methanesulfonyl chloride. The mixture was allowed to come to room temperature overnight and diluted to 500 ml by the addition of ethyl acetate, with stirring. The resulting solid was then filtered off, washed with acetone and dried in air to give 1-[4-(4-chlorophenyl)-2-(methanesulfonyloxy)-n-butyl]imidazole hydrochloride as a white solid (27.4 g).

1. temperaturewas cooled in an ice bath
2. additiontreated dropwise
3. filtrationThe resulting solid was then filtered off
4. washwashed with acetone
5. customdried in air