反应详情

A solution of 7-hydroxynaphthalene-2-carboxylic acid (56.09 g) in ethanol (200 ml) was saturated with dry hydrogen chloride and then refluxed for 30 minutes. The mixture was evaporated to about half volume, treated with water, and extracted with ethyl acetate, which was washed with water, and sodium bicarbonate solution, dried and evaporated to give a solid. Crystallisation from ethyl acetate afforded ethyl 7-hydroxynaphthalene-2-carboxylate (37.5 g), m.p. 155°-156°.

1. temperaturerefluxed for 30 minutes
2. customThe mixture was evaporated to about half volume
3. additiontreated with water
4. extractionextracted with ethyl acetate, which
5. washwas washed with water, and sodium bicarbonate solution
6. customdried
7. customevaporated
8. customto give a solid
9. customCrystallisation from ethyl acetate