反应详情

4-Hydroxy-3-iodobenzonitrile was prepared by the method analogous to Preparation 341 above using N-iodosuccinimide, acetic acid, sulfuric acid and 4-Hydroxybenzonitrile. Purified by ISCO™ (80 g SiO2) eluting with ethyl acetate:heptane (gradient 0:1 to 3:7, by volume) to yield the title compound.

1. custom4-Hydroxy-3-iodobenzonitrile was prepared by the method analogous to Preparation 341
2. customPurified by ISCO™ (80 g SiO2)
3. washeluting with ethyl acetate