HRID463341

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID11843

2-Methyl-1,3-benzenediol

C7H8O2

HCID20282950

未命名化合物

PRODUCTS

生成物

结构：CCCc1c(OCCCOc2ccc3cc(C(=O)OC)oc3c2C)ccc(C(C)=O)c1O

HCID20282956

未命名化合物

HCID20282979

未命名化合物

HCID20282993

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID887

Methanol

CH4O

溶剂HCID8857

Ethyl acetate

C4H8O2

PROCEDURE

实验过程

2,6-Dihydroxytoluene was converted by the methods of Example 2(a), (b) and (c) to methyl 2-[3-benzyloxy-6-formyl-2-methylphenoxy]acetate, mp 64°-66°, which by the methods of Example 2(d) and (e) and Example 5(b) gave successively methyl 6-benzyloxy-7-methylbenzofuran-2-carboxylate, mp 117°-120° (from ethyl acetate), methyl 6-hydroxy-7-methylbenzofuran-2-carboxylate, mp 144°-147° (decomp.) and methyl 6-[3-(4-acetyl-3-hydroxy-2-propylphenoxy)propoxy]-7-methylbenzofuran-2-carboxylate, mp 123°-124° from methanol).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-f07613b2673347d3885449c3575f61bd
来源数据集: uspto-grants-1985_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04518612
来源说明: uspto-grants-1985_05

反应 SMILES

[OH:1]C1C=CC=C(O)C=1C.COC1C=CC(CCCCCOC2C=CC=C3C=2C=CC=C3OCC([O-])=O)=CC=1CCC.[Na+].CC1C2C=CC(SCCCCCC3C=CC=CC=3)=C(CCC)C=2OC=1C([O-])=O.[Na+].[CH2:72]([O:79][C:80]1[C:81]([CH3:94])=[C:82]([C:89]([CH:92]=O)=[CH:90][CH:91]=1)[O:83][CH2:84][C:85]([O:87][CH3:88])=[O:86])[C:73]1[CH:78]=[CH:77][CH:76]=[CH:75][CH:74]=1.[OH:95][C:96]1[CH:109]=[CH:108][C:99]2[CH:100]=[C:101]([C:103]([O:105][CH2:106]C)=[O:104])[O:102][C:98]=2[C:97]=1[CH2:110][CH2:111][CH3:112]>CO.C(OCC)(=O)C>[CH2:72]([O:79][C:80]1[CH:91]=[CH:90][C:89]2[CH:92]=[C:84]([C:85]([O:87][CH3:88])=[O:86])[O:83][C:82]=2[C:81]=1[CH3:94])[C:73]1[CH:78]=[CH:77][CH:76]=[CH:75][CH:74]=1.[OH:95][C:96]1[CH:109]=[CH:108][C:99]2[CH:100]=[C:101]([C:103]([O:105][CH3:106])=[O:104])[O:102][C:98]=2[C:97]=1[CH3:110].[C:100]([C:99]1[CH:108]=[CH:109][C:96]([O:95][CH2:78][CH2:73][CH2:72][O:79][C:80]2[CH:91]=[CH:90][C:89]3[CH:92]=[C:84]([C:85]([O:87][CH3:88])=[O:86])[O:83][C:82]=3[C:81]=2[CH3:94])=[C:97]([CH2:110][CH2:111][CH3:112])[C:98]=1[OH:102])(=[O:1])[CH3:101]