反应详情

A solution of ethyl 2-methoxyimino-3-oxobutyrate (syn isomer 17.3 g), ethylene glycol (12.4 g) and p-toluenesulfonic acid (0.5 g) in benzene (260 ml) was heated under reflux while removing water. The resultant solution was washed with a saturated aqueous solution of sodium bicarbonate and a saturated aqueous solution of sodium chloride in turn and dried over magnesium sulfate. After evaporating the solvent from the solution, the residue was distilled under reduced pressure to give ethyl 2-methoxyimino-3,3-ethylenedioxybutyrate (syn isomer, 15.2 g), bp 97° to 102° C./4 mmHg.

1. temperatureunder reflux
2. customwhile removing water
3. washThe resultant solution was washed with a saturated aqueous solution of sodium bicarbonate
4. dry with materiala saturated aqueous solution of sodium chloride in turn and dried over magnesium sulfate
5. customAfter evaporating the solvent from the solution
6. distillationthe residue was distilled under reduced pressure