Thionyl Chloride → HCID 13300848, compound

Participants

Reaction Steps

3-(4(p-trifluoromethylphenoxy)phenyl)-4-phenylbutyric acid (23 g) was refluxed in benzene with thionyl chloride (46 ml) for one hour. The solution was then evaporated to dryness and the residue dissolved in benzene (23 ml). A solution of stannic chloride (23 g) in benzene (46 ml) was added at 0° with stirring. The solution was allowed to stir at 0° for 0.5 hr. Ice; water, diethylether and dilute HCl were then added sequentially. The ether extracts were further washed with aqueous potassium hydroxide and evaporated to give 3-(4-(p-trifluoromethylphenoxy)phenyl)tetralone m.p. 136°-137° (ethanol).

Provenance & Evidence