Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dichloromethane → HCID 13457850, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dichloromethane | HCID 6344 | — |
| 반응물 | alpha-Bromo-4-chlorophenylacetic acid | HCID 10490868 | — |
| 반응물 | HCID 178481665 | HCID 178481665 | — |
| 용매 | Triethylamine | HCID 8471 | — |
| 생성물 | HCID 13457850 | HCID 13457850 | 41% |
반응 단계
A methylene chloride solution of 3.3 g (0.02M) of 2-mercapto-1-methyl-1H-benzimidazole, 5.0 g (0.02M) of α-bromo-(p-chlorophenyl)acetic acid and 4.0 g (0.04M) of triethylamine is heated to reflux overnight. The reaction mixture is neutralized with a diluted HCL solution. The layers are separated and the organic layer is dried over anhydrous magnesium sulfate. After removal of methylene chloride the residue is recrystallized from acetonitrile. The recrystallized material weighs 4.1 g (41% yield) and has a melting point of 161°-3° C. dec.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04520196 |
| 출처 데이터셋 | uspto-grants-1985_05 |
| ORD ID | ord-d0ca4776a20d40edbe0eb7f5c3e47d45 |
| 출처 메모 | uspto-grants-1985_05 |