反应详情

5.96 g (0.03M) of 5-Chloro-2-mercapto-1-methylbenzimidazole of C above, 0.5 g (0.03M) of α-bromophenylacetic acid and 6.0 g (0.06M) of triethylamine are dissolved in methylene chloride (200 ml) and the mixture heated to reflux overnight. The basic solution is washed with a diluted HCl solution and a white solid is collected. The crude material is recrystallized from 5 L of acetonitrile to give 6.0 g (60% yield) of the title compound, m.p. 203°-5° C. dec.

1. temperaturethe mixture heated
2. temperatureto reflux overnight
3. washThe basic solution is washed with a diluted HCl solution
4. customa white solid is collected
5. customThe crude material is recrystallized from 5 L of acetonitrile