反应详情

To a mixture of methyl P-methyl-2-nitro-5-phenylthiophenylphosphinate (3.0 g) and ammonium chloride (5.3 g) in 40 ml of ethanol and 20 ml of water is heated to 70°, and iron (3.0 g) is added portionwise over a period of about 10 minutes. After the reaction is completed, the reaction mixture is filtered and the filtrate is concentrated to a small volume, followed by extraction with methylene chloride, drying and evaporation to give methyl P-methyl-2-amino-5-phenylthiophenylphosphinate.

1. temperatureis heated to 70°
2. filtrationthe reaction mixture is filtered
3. concentrationthe filtrate is concentrated to a small volume
4. extractionfollowed by extraction with methylene chloride
5. customdrying
6. customevaporation