Ethanol → HCID 54040739, compound

HRID 463558Notes

Reaction equation

HRID 463558 reaction equation
[OH-].[K+].[CH3:3][P:4]([C:9]1[CH:14]=[C:13](Cl)[CH:12]=[CH:11][C:10]=1[N+:16]([O-:18])=[O:17])(=[O:8])[O:5][CH2:6][CH3:7].[CH2:19]([OH:21])[CH3:20]>>[CH3:3][P:4]([C:9]1[CH:14]=[C:13]([O:21][CH2:19][CH3:20])[CH:12]=[CH:11][C:10]=1[N+:16]([O-:18])=[O:17])(=[O:8])[O:5][CH2:6][CH3:7]

Participants

4

Reactant 3

HCID 702EthanolHCID 14797Potassium HydroxideHCID 53860251ethyl P-methyl-2-nitro-5-chlorophenylphosphinate

Product 1

HCID 54040739HCID 54040739, compound

Procedure

To a solution of potassium hydroxide pellets (10.0 mmol) dissolved in ethanol (B 50 ml) is added ethyl P-methyl-2-nitro-5-chlorophenylphosphinate (20.0 mmol). The mixture is boiled for 48 hours and is then concentrated to a slurry. The residue is diluted with water, acidified with 10% HCl and extracted with ethyl acetate (2×). The combined extracts are washed with brine, dried and evaporated to yield ethyl P-methyl-2-nitro-5-ethoxyphenylphosphinate.

Workup

  1. concentrationis then concentrated to a slurry
  2. additionThe residue is diluted with water
  3. extractionextracted with ethyl acetate (2×)
  4. washThe combined extracts are washed with brine
  5. customdried
  6. customevaporated

Sources & evidence

ORD record
ord-12c7a5958ab74bf787abf64c163dd3d1
Source dataset
uspto-grants-1985_05
Patent number
US04520197

Reaction notes

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