Ethanol → ethyl P-methyl-2-nitro-5-ethoxyphenylphosphinate

Participants

Reaction Steps

To a solution of potassium hydroxide pellets (10.0 mmol) dissolved in ethanol (B 50 ml) is added ethyl P-methyl-2-nitro-5-chlorophenylphosphinate (20.0 mmol). The mixture is boiled for 48 hours and is then concentrated to a slurry. The residue is diluted with water, acidified with 10% HCl and extracted with ethyl acetate (2×). The combined extracts are washed with brine, dried and evaporated to yield ethyl P-methyl-2-nitro-5-ethoxyphenylphosphinate.

Provenance & Evidence