HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethyl phosphite → 5-(2-Chloro-4-trifluoromethylphenoxy)benzo-2,1,3-oxadiazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethyl phosphite | HCID 31215 | — |
| Reactant | 5-(2-chloro-4-trifluoromethylphenoxy)benzo-2,1,3-oxadiazole N-oxide | HCID 13534336 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 5-(2-Chloro-4-trifluoromethylphenoxy)benzo-2,1,3-oxadiazole | HCID 13534337 | — |
Reaction Steps
A mixture of 5-(2-chloro-4-trifluoromethylphenoxy)benzo-2,1,3-oxadiazole N-oxide (2.0 g) and triethyl phosphite (10 ml) is heated under reflux in ~150 ml of ethanol for 4 hours. The reaction is cooled and stripped, and the crude product is purified by prep. TLC (15% ethyl acetate/hexane) to give 5-(2-chloro-4-trifluoromethylphenoxy)benzo-2,1,3-oxadiazole, m.p. 65°-66°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04544400 |
| Source dataset | uspto-grants-1985_10 |
| ORD ID | ord-cf310e67826c4446abb932517a161b5c |
| Source note | uspto-grants-1985_10 |