Ethanol → Benzenamine, 5-(2,4-dichlorophenoxy)-2-nitro-

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Reaction Steps

N-methylcarbonyl 2-nitro-5-(2,4-dichlorophenoxy)aniline (2.0 g, 5.9 mmol) in 50 ml of 10% hydrochloric acid is heated under reflux for 2 hours. The reaction is cooled to RT, 10 ml of ethanol is added, and the reaction is heated under reflux for another 4 hours. The reaction is cooled to RT, made slightly basic with 20% sodium hydroxide and extracted with ether. The combined extracts are washed with water, dried and stripped to give 2-nitro-5-(2,4-dichlorophenoxy)aniline.

Provenance & Evidence