反应详情

N-methylcarbonyl 2-nitro-5-(2,4-dichlorophenoxy)aniline (2.0 g, 5.9 mmol) in 50 ml of 10% hydrochloric acid is heated under reflux for 2 hours. The reaction is cooled to RT, 10 ml of ethanol is added, and the reaction is heated under reflux for another 4 hours. The reaction is cooled to RT, made slightly basic with 20% sodium hydroxide and extracted with ether. The combined extracts are washed with water, dried and stripped to give 2-nitro-5-(2,4-dichlorophenoxy)aniline.

1. temperatureunder reflux for 2 hours
2. temperaturethe reaction is heated
3. temperatureunder reflux for another 4 hours
4. temperatureThe reaction is cooled to RT
5. extractionextracted with ether
6. washThe combined extracts are washed with water
7. customdried