Palmitic Acid → Palmitoyl chloride

HRID 463640Notes

Reaction equation

HRID 463640 reaction equation
[C:1]([OH:18])(=O)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16].S(Cl)([Cl:21])=O>>[C:1]([Cl:21])(=[O:18])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16]

Participants

3

Reactant 2

HCID 985Palmitic AcidHCID 24386Thionyl Chloride

Product 1

HCID 8206Palmitoyl chloride

Procedure

Palmitic acid (1 mole) is heated with thionyl chloride (20 mole) at 75° C. for 2 hours. The thionyl chloride is removed by distillation at atmospheric pressure and the palmitoyl chloride is then separated by distillation under reduced pressure.

Workup

  1. customThe thionyl chloride is removed by distillation at atmospheric pressure
  2. customthe palmitoyl chloride is then separated by distillation under reduced pressure

Sources & evidence

ORD record
ord-e719b4dd08654a40988f8719fb833c17
Source dataset
uspto-grants-1985_10
Patent number
US04544504

Reaction notes

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