Palmitoyl chloride → HCID 11108028, compound

Participants

Reaction Conditions

Reaction Steps

Palmitoyl chloride (651 mg, 2.2 mole) was added to pyridinium poly(hydrogen fluoride) (1 ml) in a teflon reaction vial and the mixture stirred at 20° C. for 20 min. After cooling to 0° C., it was quenched with ice-water (5 ml), extracted with ethyl acetate, and the organic layer washed (water, brine), dried over anhydrous magnesium sulfate, concentrated and evaporatively distilled (120° C./0.025 torr) to give palmitoyl fluoride (76%) (contaminated with 5% of the corresponding acid). Since this concentration of contaminant is not harmful to the biological activity of the compound, no further purification is required.

Provenance & Evidence