化工社化工社 化学情報印刷レポート · 研究参考用
Ethoxyacetyl chloride → 6-[p-(ethoxyacetylamino)-phenyl]-4,5-dihydro-5-methyl-3(2H)-pyridazinone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethoxyacetyl chloride | HCID 84189 | — |
| 反応物 | Ici 109,081 | HCID 161928 | — |
| 溶媒 | Acetone | HCID 180 | — |
| 生成物 | 6-[p-(ethoxyacetylamino)-phenyl]-4,5-dihydro-5-methyl-3(2H)-pyridazinone | HCID 13193376 | 51.2% |
反応手順
20.3 g (0.1 mole) of 6-(p-aminophenyl)-4,5-dihydro5-methyl-3(2H)-pyridazinone were stirred with 14.7 g (0.12 mole) of ethoxyacetyl chloride and 400 ml of absolute acetone for 10 hours at room temperature. The product was filtered off under suction at 10° C., washed with cold acetone and dried at 70° C. under reduced pressure. 14.8 g (51%) of 6-[p-(ethoxyacetylamino)-phenyl]-4,5-dihydro-5-methyl-3(2H)-pyridazinone were obtained. Mp.: 195°-197° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04544562 |
| 出典データセット | uspto-grants-1985_10 |
| ORD ID | ord-f7163688a02c42ba8655b08a349fa603 |
| 出典メモ | uspto-grants-1985_10 |