反应详情

20.3 g (0.1 mole) of 6-(p-aminophenyl)-4,5-dihydro5-methyl-3(2H)-pyridazinone were stirred with 14.7 g (0.12 mole) of ethoxyacetyl chloride and 400 ml of absolute acetone for 10 hours at room temperature. The product was filtered off under suction at 10° C., washed with cold acetone and dried at 70° C. under reduced pressure. 14.8 g (51%) of 6-[p-(ethoxyacetylamino)-phenyl]-4,5-dihydro-5-methyl-3(2H)-pyridazinone were obtained. Mp.: 195°-197° C.

1. filtrationThe product was filtered off under suction at 10° C.
2. washwashed with cold acetone
3. customdried at 70° C. under reduced pressure