反应详情

A solution of α-hydroxyethylphosphinic acid (2.2 g) and 1-butanol (5.0 g) in benzene (30 ml) was heated for 3 hours with removal of water through a Dean-Stark apparatus. After cooling, the reaction mixture was washed with water, dried over magnesium sulfate and concentrated in vacuo to give 2.71 g (81.6%) of n-butyl α-hydroxyethylphosphinate (Compound No. 5).

1. temperatureAfter cooling
2. washthe reaction mixture was washed with water
3. dry with materialdried over magnesium sulfate
4. concentrationconcentrated in vacuo