1-Butanol → HCID 178454804, compound

HRID 463670Notes

Reaction equation

HRID 463670 reaction equation
[OH:1][CH:2]([PH:5](=[O:7])[OH:6])[CH2:3][Cl:4].[CH2:8](O)[CH2:9][CH2:10][CH3:11].O>C1C=CC=CC=1>[OH:1][CH:2]([PH:5](=[O:6])[O:7][CH2:8][CH2:9][CH2:10][CH3:11])[CH2:3][Cl:4]

Participants

5

Reactant 3

HCID 2631-ButanolHCID 962WaterHCID 178527059HCID 178527059, compound

Product 1

HCID 178454804HCID 178454804, compoundYield 64.8%

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

A solution of α-hydroxy-β-chloroethylphosphinic acid (2.9 g) and 1-butanol (10.0 g) in benzene (30 ml) was heated for 3 hours with removal of water through a Dean-Stark apparatus. The same work-up as in Example 6 gave 2.60 g (64.8%) of n-butyl α-hydroxy-β-chloroethylphosphinate (Compound No. 82).

Sources & evidence

ORD record
ord-bb8bc40edb864365be34705c2d07cf42
Source dataset
uspto-grants-1985_10
Patent number
US04544652

Reaction notes

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