反应详情

2.09 g of 9-methoxyacridine are dissolved in 50 ml of dry ethanol, treated with a solution of 1.98 g of 2-hydrazino-2-thiazoline hydrobromide in 50 ml of dry ethanol, heated to boiling under reflux for 1 hour and the solvent is removed in vacuo. The residue is treated with aqueous ammonia (1:5) and extracted with ethyl acetate. After drying the extract over sodium sulfate and evaporation, the material obtained is crystallized by the addition of pentane. There is obtained 9-acridanone (2-thiazolidinylidene)hydrazone of melting point 214°-215° (decomposition).

1. temperatureheated
2. temperatureunder reflux for 1 hour
3. customthe solvent is removed in vacuo
4. additionThe residue is treated with aqueous ammonia (1:5)
5. extractionextracted with ethyl acetate
6. customAfter drying the
7. extractionextract over sodium sulfate and evaporation
8. customthe material obtained
9. customis crystallized by the addition of pentane