Methanol → HCID 20265093, compound

HRID 463754Notes

Reaction equation

HRID 463754 reaction equation
[O:1]1[CH2:18][CH:2]1[CH2:3][O:4][C:5]1[CH:6]=[CH:7][C:8]2[CH:12]=[C:11]([S:13](=[O:16])(=[O:15])[NH2:14])[O:10][C:9]=2[CH:17]=1.[CH3:19][OH:20]>S(=O)(=O)(O)O>[CH3:19][O:20][CH2:18][CH:2]([OH:1])[CH2:3][O:4][C:5]1[CH:6]=[CH:7][C:8]2[CH:12]=[C:11]([S:13](=[O:15])(=[O:16])[NH2:14])[O:10][C:9]=2[CH:17]=1

Participants

4

Reactant 2

HCID 887MethanolHCID 20265040HCID 20265040, compound

Product 1

HCID 20265093HCID 20265093, compound

Reagents, catalysts & solvents 1

HCID 1118Sulfuric AcidCatalyst

Procedure

One drop of concentrated sulfuric acid is added to a solution of 6-[2,3-epoxypropoxy]-2-sulfamoylbenzo[b]furan (7.0 mmol) in methanol (25 ml). After 18 hours, the methanol is removed under vacuum. The residue is dissolved in ethyl acetate (200 ml), washed with water (2×25 ml), brine (2×25 ml) and dried (Na2SO4). The ethyl acetate is removed under vacuum. The white solid remaining is recrystallized from boiling ethyl acetate.

Workup

  1. customthe methanol is removed under vacuum
  2. dissolutionThe residue is dissolved in ethyl acetate (200 ml)
  3. washwashed with water (2×25 ml), brine (2×25 ml)
  4. dry with materialdried (Na2SO4)
  5. customThe ethyl acetate is removed under vacuum
  6. customThe white solid remaining is recrystallized

Sources & evidence

ORD record
ord-18cf9ac8e62b472b9af7d30c476d0a6c
Source dataset
uspto-grants-1985_10
Patent number
US04544667

Reaction notes

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