Methyl iodide → 5-Methoxymethylbenzo[b]furan

HRID 463758Notes

Reaction equation

HRID 463758 reaction equation
[OH-].[K+].[OH:3][CH2:4][C:5]1[CH:13]=[CH:12][C:8]2[O:9][CH:10]=[CH:11][C:7]=2[CH:6]=1.[CH3:14]I>CS(C)=O>[CH3:14][O:3][CH2:4][C:5]1[CH:13]=[CH:12][C:8]2[O:9][CH:10]=[CH:11][C:7]=2[CH:6]=1

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 14797Potassium HydroxideHCID 27951791-Benzofuran-5-ylmethanol

Product 1

HCID 202650535-Methoxymethylbenzo[b]furan

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent2×

Procedure

To a stirred mixture of powdered KOH in dimethylsulfoxide is added 5-hydroxymethylbenzo[b]furan in dimethylsulfoxide. Then methyl iodide is added dropwise at ambient temperature over several minutes to provide the title compound.

Sources & evidence

ORD record
ord-e005b215c04741cdbcd123a081bde0c3
Source dataset
uspto-grants-1985_10
Patent number
US04544667

Reaction notes

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