O-Methylhydroxylamine hydrochloride → 2-Methoxyimino-2-(3-chloro-4-hydroxyphenyl)acetic acid

HRID 463835Notes

Reaction equation

HRID 463835 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:9](=O)[C:10]([OH:12])=[O:11])[CH:5]=[CH:6][C:7]=1[OH:8].Cl.[CH3:15][O:16][NH2:17]>>[CH3:15][O:16][N:17]=[C:9]([C:4]1[CH:5]=[CH:6][C:7]([OH:8])=[C:2]([Cl:1])[CH:3]=1)[C:10]([OH:12])=[O:11]

Participants

3

Reactant 2

HCID 521874O-Methylhydroxylamine hydrochlorideHCID 129611392-(3-Chloro-4-hydroxyphenyl)-2-oxoacetic acid

Product 1

HCID 1360939502-Methoxyimino-2-(3-chloro-4-hydroxyphenyl)acetic acid

Procedure

2-(3-Chloro-4-hydroxyphenyl)glyoxylic acid (6.45 g.) and O-methylhydroxylamine hydrochloride (2.74 g.) were reacted according to a similar manner to that of Preparation (5-3)(a) to give oil of 2-methoxyimino-2-(3-chloro-4-hydroxyphenyl)acetic acid (a mixture of syn and anti isomers) (7 g.).

Sources & evidence

ORD record
ord-a9ea8deb4f964f1687c6a08961b26dc9
Source dataset
uspto-grants-1985_10
Patent number
US04544653

Reaction notes

Loading…