反应详情

A mixture of 9(R)-bromoacetyl-6,9,11-trihydroxy-5,7,8,9,10,12-hexahydronaphthacene-5,12-dione (1.00 g) obtained in Reference Example 4-(1), sodium octate (4.8 g) and acetone (50 ml) was stirred under reflux for 3 hours, cooled to room temperature and concentrated under reduced pressure. The residue was triturated with addition of ether (15 ml). Solid substances were filtered to give orange crystals of 9(R)-octyloxyacetyl-6,9,11-trihydroxy-5,7,8,9,10,12-hexahydronaphthacene-5,12-dione. M.P., 144°-148° C.

1. temperatureunder reflux for 3 hours
2. concentrationconcentrated under reduced pressure
3. customThe residue was triturated with addition of ether (15 ml)
4. filtrationSolid substances were filtered