反应详情

To a solution of 33.61 gms of glycine t-butyl ester and 27.19 gms of benzaldehyde in 215 ml benzene was added 21.5 gms of magnesium sulfate in one portion with stirring at room temperature. The reaction was stirred 18 hours at room temperature, filtered, diluted with ether and washed with saturated sodium bicarbonate and brine. The ether solution was then dried over magnesium sulfate, concentrated and distilled to yield 48.41 gms (86%) of t-butyl N-benzylideneglycinate.

1. stirringThe reaction was stirred 18 hours at room temperature
2. filtrationfiltered
3. additiondiluted with ether
4. washwashed with saturated sodium bicarbonate and brine
5. dry with materialThe ether solution was then dried over magnesium sulfate
6. concentrationconcentrated
7. distillationdistilled