Hydrochloric Acid → HCID 178517314, compound

HRID 464256Notes

Reaction equation

HRID 464256 reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]1[CH:12]=[N:13][N:14]=[C:7]1[C:6]([O:15]C)=[N:5]2.Cl>C(O)(=O)C>[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]1[CH:12]=[N:13][N:14]=[C:7]1[C:6]([OH:15])=[N:5]2

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 13385681HCID 13385681, compound

Product 1

HCID 178517314HCID 178517314, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A mixture consisting of 11.3 g (0.52 mole) of 7-fluoro-4-methoxy-[1,2,4]triazolo[4,3-a]quinoxaline, 115 ml. of 1N hydrochloric acid and 345 ml. of glacial acetic acid was refluxed for a period of three hours. Upon completion of this step, the reaction mixture was cooled to room temperature and poured over ice/water. The resulting mixture was then stirred for a period of 30 minutes and thereafter filtered to remove the precipitate, which was subsequently washed with water and air-dried to ultimately afford 8.9 g. (84%) of pure 7-fluoro-4-hydroxy-[1,2,4]triazolo[4,3-a]quinoxaline, m.p.>300° C. Mass Spectrum: m/e, 204 (P).

Workup

  1. filtrationfiltered
  2. customto remove the precipitate, which
  3. washwas subsequently washed with water
  4. customair-dried to ultimately afford 8.9 g

Sources & evidence

ORD record
ord-19434b2b2aba48eaa8a8c003a67cef7c
Source dataset
uspto-grants-1985_10
Patent number
US04547501

Reaction notes

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